1.Formic Acid Method
It is generated by formic acid and methanol esterification methyl formate. And then dimethylamine gas instead should be generated dimethylformamide. Then get N,N-dimethylformamide through pressurizing and rectification methanol and methyl formate recovered by distillation.
2. One Step Method
The direct reaction of dimethylamine and carbon monoxide in sodium methanol. Reaction conditions are 1.5~2.5 MPa and 110~150℃. N,N-dimethylformamide can be obtained by rectifying the crude products.
3. High-Pressure Method
Carbon dioxide and methanol under high pressure and 80~100℃ temperature by carbonyl synthesis of methyl formate. Then, the reaction with dimethylamine dimethyl formamide generates N,N-dimethylformamide after distillation.
4. Trichloroacetaldehyde Method
By the reaction of Trichloroacetaldehyde and Dimethylamine, get N,N-dimethylformamide.