1.Formic Acid Method
Generated by formic acid and methanol esterification methyl formate. And then with dimethylamine gas instead should be generated dimethylformamide. Then get N, N-dimethylformamide through pressurizing and rectification methanol and methyl formate recovered by distillation.
2. One Step Method
The direct reaction of dimethylamine and carbon monoxide in the action of sodium methanol. Reaction conditions is 1.5 ~ 2.5 MPa and 110 ~ 150 ° C. N, N-dimethylformamide can be gotten by rectification the crude products.
3. High-Pressure Method
By carbon dioxide and methanol under high pressure and 80 ~ 100 ° C temperature by carbonyl synthesis of methyl formate. Then generated by reaction with dimethylamine dimethyl formamide, get N, N-dimethylformamide after distillation.
4. Trichloroacetaldehyde Method
By the reaction of Trichloroacetaldehyde and Dimethylamine, get N, N-dimethylformamide.